On a mac at least, the Georgia is not easy to read when writing a new piece, and the admin menu is a bit clunky with the "display: inline" making everything look a little awkward. So...
I've made a stylesheet to address these issues, which still uses the blue and grey and still looks like WordPress, just with Lucida or Verdana specified and the menu display edited.
It works in Safari and Firefox on a Mac, uses "float: left', "display: block" and "font-size: 1em"; seems to work OK in IE PC but won't work in Mac IE.
It's a stylesheet change only, and y0u can see a screenshot at "www.jamesbisset.com/pics/wp-admin.gif".
The styleheet is at "www.jamesbisset.com/wp-admin.css"
Feel free to fiddle and tweak, though it may be superceded by WP 1.3?