Responsive Webdesign

Greetings

after reading ‘responsive webdesign’ by ethan Marcotte and surfed around the inet searching on RD, I really want to give it a go

I have hand coded a few HTML5 page with RD in mind and I have been hooked

now I would like to go the next step and try to use a boilerplate solution to speed up my developpement, and learn new things

I came accross 320andup http://stuffandnonsense.co.uk/projects/320andup/ that looks very nice and a very good addition to HTML5 Boilerplate, which look like one reference

then I came accross the theme bones http://themble.com/bones/ which look like it is based on 320andup

I was wondering if anyone here had experience with RD in general and using 320andup in particular? if any of you tried Bones. since my idea is to use it with WP, I would love NOT to reinvent the wheel by making a 320andup based theme, if Bones is exactly that. then I could use Bones as a base

or maybe it is not the best way to go and someone has better advises for me

Thank you in advance for all your point of view