My dedicated web server has the URL Rewrite module installed and I have followed everything from http://codex.wordpress.org/Using_Permalinks ,also found other links on Google that have helped but not quit cracked it (see end of post), and the pretty permalinks are working fine if you go to a post, for example http://www.cccit.co.uk/news/test-post.
However, navigating to the home page results in a 404. So, http://www.cccit.co.uk/news is getting the 404. Disabling pretty permalinks from within my wordpress login will cause this error to go away.
Any help would be my appreciated.
http://ruslany.net/2009/05/iis-7-url-rewrite-module-support-in-wordpress-28/ (have also posted here)