It can be used, but it most certainly, as can be seen on its own page, breaks some, or all, ajax plugins and theme functions.
Yes you can use it. You will have some problems if you use other plugins like Contact Form 7. Somehow headspace2 mixed up the parsing. After I put in some content into the headspace2 bxoes like keywords and description it worked again.
If you are referring to some bug reports I have not been able to reproduce any of the issues and it is likely something specific to the environment (server settings, other plugins etc).
Johnny,
I love this plug, to the point that I use it even though it breaks others. If you want, leave me a message at arielsilverstone.com and I will give you whatever information you need to help find out why this is going on.
Ariel