Primarily for use in new WP installations, the steps are based on an employee checklist from Search Commander, Inc. for setting up sites.
We recommend disabling any other plugins before running the process to minimize potential confilcts. There will be no conflicts when you re-enable them.
Your .htaccess file should be writable for your permalinks to change.
The permalink option is "on" by default. If you've already set your permalinks and forgot to uncheck the option box, you can easily go back and change back to your original settings in wp-admin > Settings > Permalinks.