Something that kinda irks me is the lack of "moderate this", "approve this", "mark as spam" template tags. Yes, I can edit the post and do it from there, but it would be really neat (not no mention a lot quicker, since firing up the entire wp-admin environment is not fun on a slow connection or computer) if there would be links for immediately deleting / approving / moderating a comment from the front-end. It would be hella neat if I could do it from within the "there's a new comment"/"there's a new moderated comment" e-mail I receive. Right now I can only delete a comment, and I might want to do something else with it.
Making the front-end links use AJAX for improved speed would be a bonus, as would be the option to have the mail links bypass the "are you sure..." pages. Yes, I'm sure, otherwise I wouldn't have clicked the damn link, thank you. =]
This also makes things easier for the mobile users, without the need to port the entire admin section to mobile form, as requested here.
I know this would be not-too-hard to code in a plugin, but having it in the core would be great.