It would be nice if there was a program that helps you build your own theme (visually, i.e. for non programmers), and then converts the final piece to a format wordpress understands.
When you build your site you will be able to choose your background, font, styles for headings, how many columns, location. etc. etc. etc. Or more sophisticated - you could design your theme like you would on a program like frontpage.
Maybe you would be able to edit other people's themes on this program. For non programmers like myself (and i assume the majority of users), even trying to change small things on other peoples themes can be a nightmare, but if it was presented visually, it should be no problem.
Please create this, someone!