Ok, so this has got to be one of the stranger issues I have seen - its like the site is loading the CSS of the theme once and then on refresh it does not, then refresh again and its fine. If I switch to the wordpress default theme everything is fine - but if I use the new K2 theme this problem occurs - I've also disabled all plugins except Akismet.
Thoughts?
http://www.wetwired.org is the site.