just post this to share an error i was having after upgrading to 3.0.1 from 2.9.2
I was using WordPress MU with memcached object cache with memcached php module stable version 2.2.5 from http://pecl.php.net/package/memcache
After upgrading to 3.0.1 and changing the rewrite rules to ms-files.php instead of blogs.php to manage the files of multisite blogs the images and files in blogs were not showed having this error in logs "zend_mm_heap corrupted"
I am using nginx as a webserver and php-fpm but this error was also present in apache with php module. The difference is that nginx never showed the images and apache sometimes.
Upgrading memcached php module from stable 2.2.5 to beta 3.0.4 from here http://pecl.php.net/package/memcache solved the problem