Still in the debugging phase but thought I'd throw it out there incase I was right, I updated Subscribe2 on our Multisite install about an hour ago and since then we're getting MySQL errors that is breaking replication between servers.
Last_SQL_Error: Error 'Duplicate column name 'conf_ip'' on query. Default database: 'bla_36'. Query: 'ALTER TABLE wp_1081_subscribe2 ADD conf_ip char(64) AFTER conf_time'
Is this a problem with the plugin?