Yes, I am having the same problem. I have a sub-folder MultiSite installation with domain mapping and two blogs. After enabling verbose logging, and adding additional code to track the process, what appears to be happening is the upload from the form on my sub-site (blog id 2) is failing quietly at "Attempting to create directory". This is after uploading to the tmp area on the server and before creating the temporary storage area to hold the file. There is no error message, just a single "0" in the log on the line following "Attempting to create directory". This doesn't appear to be a server permissions issue, because when uploading from the main site (blog id 1) of my multisite install the plugin writes to (almost) the same area with no issue. Also, I'm getting no errors. The process just terminates.
Another worrying problem, which may be responsible for this failure, is that when the file upload process is initiated, in the log the user changes from my current logged in username on my sub-site to my other logged in username on my main site. In fact, if I log myself out of my main site, log in on my sub-site and try to upload a file (on a form which is set to only allow logged in users to see it) I get a "Someone with no permissions tried to access the inline-upload form!" error in the log and "TDOMF: Bad permissions" in the iframe on my form. This problem is confirmed by querying WordPress for the current_user user_login and and ID during the upload, which returns either the user logged in to the main site, or "0" if there is no user logged in to the main site. In addition, the directory that TDOMF tries to create (which fails) is named after the logged in user on my main site, not the current user logged in to my sub-site.
As soon as the tdomf-upload-inline process fails the user in the log (and in the current_user variable) returns to the correct current user on my sub-site. It seems like tdomf-upload-inline.php is operating in the context of a plugin on my main site, at least when it comes to users.
Could you let me know if you see the same? BTW, it's network activated, created it's tables successfully, and as far as I can tell has no other issues with multisite.