I just installed WordPress 2.8 on my server which I also recently set up. It's PHP (5.2.10, I believe) and MySQL on top of IIS 6.
Some features don't seem to be working, like moving around columns, regardless of the web browser I use.
Further, posting is painful. The text input box appears to have no text in it. You can type in it, but nothing shows up until you highlight the box. Then you can read the text. Again, regardless of web browser.
The Title box is okay.
Did I break something somehow? Am I missing a PHP extension or something?