This plugin's array of settings may be intimidating to less technically proficient users -- it took me a while to dare to tinker and getting the best combination of settings took some trial and error.
However, once you get that down, the results are well worth the effort. The supercached preloaded-page option makes pages load dramatically quicker even on a shared server -- the lag that was a constant problem before is now far more reasonable.
Also, because there are so many options, it can be used effectively with almost any site or server configuration. The flexibility it provides means you can almost certainly work around any conflicts or problems you have with it.