Just wanted to say Thank You to all the people who work on WordPress. Just upgraded from 2.6.x to 2.8.1 and had 0 problems.
Pretty much just followed all the upgrade instructions and backed EVERYTHING up before I started, disabled the plugins and went over the wp-config file with a fine-tooth comb and edited my old one as necessary.
One minor thing I did notice was that the wp-config-sample file in 2.8.1 does not contain a closing PHP tag. Not sure if it even matters or not.
Thanks again for all the hard work on WordPress.