Redefining query_post within page

hi, i cannot find my way around this.

i’m defining the content on the hp like this:

<?php
if (is_home()) {
query_posts(“cat=3&meta_key=City&meta_value=London”);
}
?>

now, i want to set links to the menue (static links) which redefines that query, e.g. to this, adding variables:

query_posts(“cat=3&meta_key=City&meta_value=London&meta_key=Bourough&meta_value!=Chelsea”);

is this even possible without reloading the whole page? setting up a page for each of the combinations is not an option.