Simon - Thanks for the input. Regarding your questions:
1- What version did you upgrade from
I've been regularly upgrading as each new release is out. But, this seems to be a known issue that folks are experiencing when upgrading from whatever to 2.2
2- If you look at your html source, what do you see in the meta values of the header ?
Yes, my content meta tags are fine, and exactly as you pasted above. This seems to be a known issue that has to do with a switch in 2.2 in the way WP handles the MySQL database character set preferences. You can Google up a fair amount of info about this, but no real definitive fix. (See also the forum posts linked to in my initial post.)
For this "in action," here's a pre-2.2 post, now displaying in WP 2.3.3:
In this case, double spaces and hyphens are appearing as question marks, but in some cases quotation marks, special characters, and other things are affected.