This problem has appeared out of nowhere on an existing blog - I haven't upgraded or installed any new plugins recently. I've seen several similar threads, but no one that specifically addresses this issue.
When I write a post, and click save or publish, the title and metadata is saved, but the content disappears.
When a comment is left on the blog, the browser hangs on wp-comments-post.php and the comment is not saved.
Also - and I'm not sure if these are related - when I log in, I am forwarded to %2Fwp-admin%2F instead of wp-admin, resulting in a 404 error. Removing the %2F's gets me to the dashboard.
I repaired all my DB tables and re-installed 2.2.1, but this has not made any difference.
All suggestions greatly appreciated