Do you use the statistic functionality? Or not?
The problem which was described in the first post can have many different origins.
One of them is that if you want to us the statistics of podPress and you have activated the recommended method "use wp permalinks", you have to use a permalink structure different from the default. It is also recommended to update the permalink settings after you have installed (or updated) podPress.
Another reason might be that you are using eventually non-ASCII characters in the file names of your podcast files. podPress 8.8.4 (and older) can not handle such file names.
These are probably the two most likely cause for the described symptoms.
But if the cause for your problem with podPress in your blog is different one then it would be helpful know which functions of podPress you are using and e.g. whether your WordPress Address is different to the Site Address or whether your blog is installed under a subdomain.
Since when have you these problems? Have you installed other plugins recently?
Or did the problems start with WP 3.0?
... this is of course another important point. podPress 8.8.4 does not work completely with WP 3.0. There might be no problems or error messages during the installation in a WP 3.0 blog but e.g. the way podPress tries to retrieve the uplooads/-folder does not work.
So, if you do not want to make a rollback to WP 2.9.2 then you could try out the latest Development Version of podPress. If you experience problems with this Development Version then please post your report in the podPress and WP 3.0 or the [Plugin: podPress] podPress 8.8.5 beta testing thread.