Since the upgrade to WP 3.3, previewing a post now gives a 404 error on sites with mapped domains.
I updated to the development version of this plugin a couple of weeks ago but it hasn't fixed this issue. Are you aware of it? I can't see if any further changes have been made to the dev version as svn seems to be down.
http://plugins.trac.wordpress.org/log/wordpress-mu-domain-mapping/
Thanks.
http://wordpress.org/extend/plugins/wordpress-mu-domain-mapping/