I'm having a few strange issues when trying to use W3TC. When the plugin is activated I have a different plugin that does not work, and I cannot edit posts.
I first noticed that my Google XML Sitemaps plugin would display a blank screen when attempting to edit the settings. It would however display the admin page menu down the left of the scren. If I disabled W3TC the plugin is functioning again and I've reproduced this on two WP sites. When I was trying to see if the plugin was generating a new sitemap and just the settings were not working I discovered another issue.
With W3TC enabled I cannot view the Posts page in the WP Admin. It too just shows up as a blank page with nothing but the black bar of the admin screen across the top. In this instance I don't even get the menu down the left.
I tried submitting a bug report from the W3TC page, but that blows up too.