I've done extensive testing of opcode caches against PHP 5.2+ and default WordPress install (the latest at a given time) and nothing scales better than APC on debian, centos/redhat/fedora in my testing.
I do believe the universal name of the game is to use gzip/mod deflate, have both a static and dynamic cache, and limit HTTP requests, load external css at the top, external js at the bottom, use CSS sprites and keep your files small. This might be an over simplification, but sometimes I just have to remind myself of what has already worked.
Yes these are some things to consider, but there's also proper use of headers, various types of caching and use of the CDN. And within any of the things we've all listed here, enumerable use cases and considerations throughout. Unfortunately, web site optimization is not plug and play, but W3TC takes you very far already (most of the optimizations are even difficult to explain to people), and will continue to press forward.