I'm currently not using Database caching on my setup.
Page caching is set to Disk Enhanced and Minify is set to Disk.
I tried using Memcached for a while and noticed that it significantly slowed down my site's loading speed (Upon first loading), so I disabled that. CPU usage / memory is not a problem as I'm on a high end dedicated. Am I better off leaving database caching disabled or using Disk / APC? (APC Had some issues on my server). Would Disk based caching increase performance? I'm not worried about the bandwidth / cpu usage savings, I'm interested in pure performance.