I haven't been able to get Subscribe to Comments Reloaded to send any emails from by blog, although I've tried many of the different types it can send.
I do receive email from own WordPress comment notification, including the emails for the comments I made to test this plugin.
I use the WP-Mail-SMTP plugin to send email which could be the source of the problem.
Another possible source is that I use MySQL version 5.0.88. I use the Optware Linux distribution and that is the latest version available.
I also have the WordPress Thread Comment plugin, but I don't think that is the source of the problem. This plugin also supports notification email, but it couldn't get it send emails, either.
I doubt I have a "multisite environment". There is only one blog on my server.