When I activate this plugin, the layout of images I have in my posts change. My images are loaded from my NextGen Gallery into my posts. I have a number of pages where I insert two or three images side by side. Once I activate this plugin, they display in a single vertical column and the anchor/link area to view the full size image now spans the entire page width. When deactivated, the anchor/link area is confined to the image itself.
I currently have the plugin deactivated because of this, but you can see an example of how the page normally looks and acts. The pictures on this page would all be in a single column if the plugin were activated, and you could click all the way to the right of the images instead of just on the image to view a larger version.