I have installed WP 3.5, jQuery Colorbox and Spectacu.la Discussion. If I activate this one, your plugin stops working.
I think this may be an issue for their side, so I've posted this message in their support site also.
The main reason I comment this is because It probably happens whith the concurrence of another ajax plugins...
I noticed a jquery error, so I added it manually which appears to have fixed colorbox.
I added an option to force loading a current jQuery version from Google to the plugin, did you try that?
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