Plug ins keep turning off

For some reason, when traffic gets high or when the server resources get hit hard, all of the plug ins turn off completely.

If the Linux server becomes unresponsive, I would reboot and apache normally turns on, however all of the plugins are turned off which causes a REALLY big problem. I would have to manually turn on all 43 plug ins.

Is this a bug, someone doing malicious things, a known issue/problem with WP?

I need help!!