I've recently built a site for someone, which I'm currently testing (http://www.audaciousdreaming.com/test/), and I'm having a bit of an issue with Safari.
Basically, as can be seen on the site, the drop down menu links are just linking to named anchors within each page. This works perfectly with Firefox, Opera and IE, but Safari doesn't seem to 'see' the hashtag for the anchor in the link. It seems happy enough with the 'top of page' links, but the menu items do not play nice.
I found a forum post somewhere (which I've now managed to lose) that said that if there is some sort of redirect in the page header that Safari will pick this up and lose it's memory of #tags in a way that other browsers won't- I don't know if this is a known issue with the twenty ten menu?