I manage a dozen websites for my clients and I run separate installations for them. Now, that I have upgraded to 3.0+ on all my client sites, I have decided to give multisite a try. I had earlier tried to set it up on my main site but the permalinks were messed up and I aborted the missing.
My main site generates a decent traffic and I don't risk messing it up or hosing it. So, I am now planning to setup a fresh multisite installation at new.mainsite.com and then have each of the client sites at new.mysite.com/client1 etc mapped to their domain. Is that possible? What is the best practice? The sites are not related to each other and so user roles have to be at the site level and one admin shouldn't be able to access another site. Would you recommend a separate multisite installation of properties I own and properties I manage?