I am looking for a CDN solution for my WordPress install of about 500 medium-traffic sites that grows by about 3 sites per day. I'd like to do origin push with Amazon Cloudfront but I can be flexible here.
I've looked at W3 Total Cache (http://wordpress.org/extend/plugins/w3-total-cache/) but you need to setup each blog individually as well as setup a new bucket for each one as per http://wordpress.org/support/topic/plugin-w3-total-cache-cdn-with-multisite?replies=3
I need something that requires a little less ongoing maintenance for each new site.
CDN Sync Tool (http://wordpress.org/extend/plugins/cdn-sync-tool/) seems to come very close to what I need, but you need to configure the CDN login settings for each site in the dashboard for each site individually - if there were a way to define the settings globally I could have what I need.