After some debugging I found two offending plugins. The one had to be completely disabled and the other was the opcode and minify settings in W3 Total Cache.
I've got APC installed and no matter if I selected disk or APC I get a white screen on the front end.
Same with Minifiy if I enable it. Once disabled output returns to normal.
I am able to install and enable Tribe Object Cache and use that as well as other minify plugins ?