This is quite a weird one. The demos is here. http://prologue.foxinni.com.
I've made my own version of Prologue but an issue has turned up. And it has to do with Permalinks and the single post.
When the permalink are set to default (?p=#) & Archive (/archive/123) the single post is inaccessible. Thats how it currently is one my theme here. It only refreshes the page.
But when it's on the longer permalink structures.. the theme works like it's suppose to. "reaching" the single and comments template.