I know, it depends on gazillions of variables, but it'd still be interesting to hear some anecdotal feedback.
I have between 500-600 posts now. My WP installation runs on a relatively high end dedicated server. Sometimes I wonder if I'm getting close to an upper limit, although there are tons of factors operating that could cause occasional slowdowns.
Anyone using WP with a HUGE number of posts without problems? I'm wondering if I should make an effort to houseclean old posts on occasion to avoid letting the database get too big.