Okay, I've read the installation page. I've hit "Save Changes" on the permalinks screen and I don't mind the thumbnails at 150x150. I saw the stuff about inserting code into the php for the theme, which is fine - I can do that.
I have a perfectly new installation of WordPress 3.5.1, and I've chosen the "Sundance" theme that came with the installation, edited the index.php file, and I've activated the Akismet plugin. That's all I've done.
But how do I actually upload a comic? I have no idea how to actually use Comic Easel, and there are no instructions anywhere that I can find about this.