I use Quick Cache for WordPress multi-site.
When I post a new article the GD Star Rating won't load anymore.
And sometimes the new post isn't even visible on the front page.
When I add a comment, it won't show.
These 3 things CAN be corrected by manually clearing the cache.
* Pruning: Single+Frontpage
* nocache uri-patterns include "ajax" and "rating"
Wp Super Cache works in all of the above regards.