I am fairly new to WordPress, but I started using it in conjunction with the Webcomic plugin for my comic. I used ComicPress a while ago, but found it a little confusing. I'm much happier with Webcomic and WordPress than I was with my tumblr account, and I have lots of updates scheduled after a minimal amount of work!
Please check out my comic (NSFW language).
PS New comics start July 5, so be sure to bookmark the page if you like it!