Here we built a site and CMS for a major entertainment magazine entirely in WordPress.
One of our key design directions was the prominent placement of user comments both on the homepage and the article pages. This has led to some really... er, interesting interaction between the mag and their old subscriber base, since the mag took a new direction and a new editor. This chatter has died down a bit and the responses have been pretty cool since.
I'd love to hear some thoughts from the dev/programming community on the design and build, more importantly what you think needs to be added/taken away to make a more effective design.