I'm in the process of filling a WordPress site with some 13,000 posts. All the posts will be of the custom post type "abstract".
I got 5,894 abstracts in the system when the /wp-admin/edit.php?post_type=abstract page (which lists all abstracts, 20 at a time) started timing out. I get a "memory size exhausted" error at /wp-includes/meta.php -- the line number varies, but it's always in the update_meta_cache function.
My memory limit is already successfully set at 128M.
I'm on a multisite install with the Domain Mapping plugin but no other plugins activated. All other backend and frontend pages are loading just fine. Any ideas?