Sorry I can't really help you but I noticed you havent had a reply after a month!!! And here I was getting frustrated at not getting a response to my question after a week.
I found your message because I'm having a 'save settings' problem but it's different to yours. I just cant get any changes in my settings page to actually stick. So... a simple thing - I want the comments to show newest first but it ignores my setting and shows newest last. NO matter what I do. What nonsense!!!!
As for your issue - I can only suggest you do a clean install of your WordPress and see if you're still having a problem.
Also - if you post a problem again maybe give more detail like what version of WordPress you're using and what plugins you had running etc. It might help - then again - it mightn't make a blind bit of difference!!!
Or, like me, you might want to consider trying some other CMS/Blog software. I'm running into so many errors and issues with WordPress 2.7 (and no-one seems to know anything or care LOL) that it's becoming a problem for my clients - therefore my business.
Good luck tho.