I just uploaded to 3.5 and am having the following issues. (I am using the My LIfe theme)
I cannot delete plugins. I can deactivate/activate them.
I cannot delete comments in my spam folder.
I cannot edit in visual or text/html mode. I think I can edit through my iPhone or iPad though.
I cannot add new media.
I cannot reply to comments in the dashboard. I can reply to comments directly on the post though.
I have issues with some of my plugins as well.