This is complicated - I need to use WP for both multiple blogs for subdirectories (which is how it is set up) as well as subdomains (which I've had to move things to.) If multisite is capable to manage other domains it should be fine handling subdomains, at least in theory.
I'm hoping to confirm that the answer is YES and if there is a guide on proper setup for such an operation.
Second question, which makes this a little complicated. Some of my databases will get large. It might make sense to have multiple databases, better load balancing, spreading the risk by not having all in one huge database, speed, etc. Is there a possible recommended setup for multiple databases but using one login/registration? I guess this is the holy grail. :)
Thank you in advance. This is one of those things you want to set up properly the first time. Right now I've got a few separate installs of WP in subdomains for the moment and want to avoid moving forward with a plugin synchronizing all those users, etc.