Exclude Category on 1 Post Index Page

Hello.

I am attempting to exclude a category from appearing on my main page when I post to it.

This code works, but only when I set the default post number to something greater than 1. If it is set at 1, nothing appears on the page.

I have also tried this suggestion and a couple of different plugins but they don’t work either.

Any ideas on how I can modify the code provided in The Loop section to continue to display one post only, and exclude posts from that category?

Thank you.