Based on the HyperDB's readme file that located in the URL http://svn.wp-plugins.org/hyperdb/trunk/readme.txt, I am not understand about what have to do exactly in the step, which on the following:
1. Edit the db settings according to the directions in that file.
Anyone has an idea on what to do on this step?
For your information, I have already setup the MySQL replication cluster that formed by 1 master server and 2 slave servers.