What theme are you using?
It depends on the theme, but try this:
1. Go to wp-admin > pages > add new
2. Set that page with sidebar template (if exists)
3. Then go to wp-admin > settings > reading
4. Set “A static page” to Front page: The page you’ve created.
If this doesn’t work, then you might have to edit the home.php template file. It’s recommended to create a child theme for customization
http://codex.wordpress.org/Child_Themes
If you are using a commercial theme, usually it has it’s own options to change the Homepage layout with or without sidebars, ask the theme author about this.
“flexform” from swift ideas