I haven’t watched it all so I don’t know how useful the presentation is. WordPress will collide with the best native web app architectures at some point…
Building Data Driven Single Page Web Applications with WordPress
I have published a minimal Single Page App WordPress theme (spa-wp-theme) on GitHub.
Minimal in the sense that it doesn’t have any supporting WordPress elements, only the front page. But it illustrates a few techniques I gathered on the internet about how to integrate some popular JS technologies (e.g. RequireJS, Handlebars, Compass, Sass, and Grunt) for use in a WordPress theme.
Hope it will help anyone trying this route.