Enable tabs in the edit screen and manage them from the back-end.
When you've got lots of post meta-boxes, your post edit screen can become difficult to search. Make your post edit screen easier to navigate and manage by creating a set of tabs, with the Tabify Edit Screen plugin. And manage it all from the WordPress back-end!
The plugin is still in active development, and I'm always looking for ways to improve it.
There are still lots of things changing in the code base. There are some hooks you can use but they can change from implementation till 1.0. I will always try to maintain backwards-compatible but till 1.0 I can't be sure for that.