One-click ColorBox lightbox integration with NextGEN Gallery. Only loads when a gallery shortcode is present.
Yes. However the small, already minified ColorBox script must be excluded from combining/minification or it won't function. This is true of any lightbox script.
For WP Minify, simply add /wp-content/plugins/nextgen-gallery-colorboxer/colorbox/js/jquery.colorbox-min.js in its js file exclusion options and clear the cache.
For W3 Total Cache, do nothing. It doesn't auto-discover, so as long as you don't manually add the script, it won't be included.
Any version since 1.6.2