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Upload the folder topical-tweets to the wp-content/plugins directory.

The main script should be at /wp-content/plugins/topical-tweets/topical-tweets.php.

Activate the plugin through the 'Plugins' menu in WordPress

If you want to use Topical Tweets in your sidebar (the recommended spot), simply add the following code in your sidebar.php file

This function will generate an unordered list (UL) element in HTML. Here is a code snippet with how your sidebar.php file should look. You can place the call to wp_topical_tweets inside sidebar directly, or you can include this code inside of a LI element that's included as part of an existing list in your sidebar display code.