Upload the extracted plugin folder and contained files to your /wp-content/plugins/ directory
Activate the plugin through the 'Plugins' menu in WordPress
Navigate to Settings -> Simply Exclude (Options -> Simply Exclude in pre 2.5).
Once on the plugin admin page you should see navigation links at the top: Manage Categories, Manage Tags, Manage Pages.On each of these page you can selectively exclude/include the cat/tag/page for the given action isfront/isarchive/isfeed/issearch.