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MyTwitter 2.0 requires PHP 5.2 or higher. This is because it is written using Twitter's JSON API and older versions of PHP do not include JSON decoding by default.

Extract the contents of the archive. Upload the mytwitter folder to your Wordpress plugins folder (e.g. http://example.com/wp-content/plugins/). Set your preferences in the Settings panel for "MyTwitter" (including username, password, cache location, and formatting options).

Establish the Cache Life to set the length of time for the Twitter feed to be cached before checking for updates.

Ensure the web server is able to write to the directory you selected for cache location in the MyTwitter Options panel.