When changing the title of your post, it would be really handy to have a Reset button next to the Edit button on the permalink line. The Reset button would simply remove the current permalink and regenerate it based on the current title.
You can currently do this by clicking edit, erasing the content, and clicking okay. I suggest that it would be clearer and a time-saver to add a Reset button.
Here's how it would look:
http://www.soapboxdave.com/2011/04/wordpress-suggestion-reset-permalink-button/